EIF4E Rabbit pAb (APR17455N)

CAT: 0882-APR17455N-03Size: 200 µLDry Ice: NoHazardous: No

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CAT#:0882-APR17455N-03Size:200 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality eIF4E Rabbit pAb (APR17455N) .

Synonyms

AUTS19; CBP; EIF4E1; EIF4EL1; EIF4F; eIF-4E; EIF4E

Gene ID

1977

UniProt

P06730

Cellular Locus

Cytoplasm, P-body

Dilution

WB 1:500 - 1:2000 IF 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 25kDa/27kDa/28kDa Observed MW: 24kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1977

Uniprot URL

https://www.uniprot.org/uniprot/P06730

AA Sequence

MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV

UniProtKB · P06730

Eukaryotic translation initiation factor 4E

IF4E_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P06730
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: EIF4E
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: eIF-4E, eIF4E
EC number: —
Processing: —
Secondary accessions: B7Z6V1, D6RCQ6, Q96E95

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Disease

AutismAutism spectrum disorder

Cellular component

CytoplasmNucleus

Biological process

Host-virus interactionmRNA transportProtein biosynthesisTranslation regulationTransport

Molecular function

Initiation factorRNA-binding

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