STAT2 Rabbit mAb (AMR12958N)

CAT: 0882-AMR12958N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-AMR12958N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality STAT2 Rabbit mAb (AMR12958N) .

Synonyms

IMD44; ISGF-3; P113; STAT113

Gene ID

6773

UniProt

P52630

Cellular Locus

Cytoplasm, Nucleus

Applications

WB (Mus musculus)

Dilution

WB 1:500 - 1:2000

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 97kDa Observed MW: 98kDa/113kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6773

Uniprot URL

https://www.uniprot.org/uniprot/P52630

AA Sequence

Email for sequence

UniProtKB · P52630

Signal transducer and activator of transcription 2

STAT2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P52630
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: STAT2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: B4DLC7, G3V2M6, Q16430, Q16431, Q9UDL4

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Biological process

Antiviral defenseHost-virus interactionTranscriptionTranscription regulation

Cellular component

CytoplasmNucleus

Disease

Disease variant

PTM

PhosphoproteinUbl conjugation

Domain

SH2 domain

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