Phospho-Pyk2-Y402 Rabbit pAb (AMR01026N)

• Background:

  This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

• Synonyms:

  PTK2B; CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2; RAFTK; Pyk2

• Gene ID:

  2185

• UniProt:

  Q14289

• Cellular Locus:

  Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Nucleus, Peripheral membrane protein, cell cortex, focal adhesion, lamellipodium, perinuclear region

• Applications:

  WB (Mus musculus)

• Dilution:

  WB 1:500 - 1:2000

• Form:

  Liquid

• Buffer:

  Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Molecular Weight:

  Calculated MW: 111kDa/115kDa Observed MW: 116kDa

• Storage Conditions:

  Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-Pyk2-Y402 Rabbit pAb (AMR01026N) .

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2185

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q14289

• AA Sequence:

  DIYAE