DHLAG (CD74) Mouse Monoclonal Antibody [Clone ID: LBI1G10]

• Background:

  The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta) . Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

• Synonyms:

  DHLAG; HLADG; Ia-GAMMA; II

• Gene Name:

  Homo sapiens CD74 molecule (CD74), transcript variant 1, mRNA.

• Gene ID:

  972

• UniProt:

  P04233

• Conjugation:

  Unconjugated

• Related Pathways:

  Antigen processing and presentation

• Field of Research:

  Antigen processing and presentation

• Dilution:

  WB 1:4000, IHC 1:150

• Form:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Buffer:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Function:

  Druggable Genome, Transmembrane

• Storage Conditions:

  Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  CD74

• Overview:

  Carrier-free (BSA/glycerol-free) CD74 mouse monoclonal antibody, clone LBI1G10

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=972

• Uniprot URL:

  https://www.uniprot.org/uniprot/P04233