SOCS3 Mouse Monoclonal Antibody [Clone ID: LBI7E10]

• Background:

  This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN) -gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq]

• Synonyms:

  ATOD4; CIS3; Cish3; SOCS-3; SSI-3; SSI3

• Gene Name:

  Homo sapiens suppressor of cytokine signaling 3 (SOCS3), transcript variant 1, mRNA.

• Gene ID:

  9021

• UniProt:

  O14543

• Conjugation:

  Unconjugated

• Related Pathways:

  Adipocytokine signaling pathway, Insulin signaling pathway, Jak-STAT signaling pathway, Type II diabetes mellitus, Ubiquitin mediated proteolysis

• Field of Research:

  Adipocytokine signaling pathway, Insulin signaling pathway, Jak-STAT signaling pathway, Type II diabetes mellitus, Ubiquitin mediated proteolysis

• Dilution:

  WB 1:2000, IHC 1:150, IF 1:100, FLOW 1:100

• Form:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Buffer:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Function:

  Druggable Genome

• Storage Conditions:

  Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  SOCS3

• Overview:

  Carrier-free (BSA/glycerol-free) SOCS3 mouse monoclonal antibody, clone LBI7E10

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=9021

• Uniprot URL:

  https://www.uniprot.org/uniprot/O14543