PDE10A Mouse Monoclonal Antibody [Clone ID: LBI1C9]

• Background:

  Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3'cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP) . They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory.

• Synonyms:

  FLJ11894; FLJ25677; HSPDE10A

• Gene Name:

  Homo sapiens phosphodiesterase 10A (PDE10A), transcript variant 2, mRNA.

• Gene ID:

  10846

• UniProt:

  Q9Y233

• Conjugation:

  Unconjugated

• Related Pathways:

  Progesterone-mediated oocyte maturation, Purine metabolism

• Field of Research:

  Progesterone-mediated oocyte maturation, Purine metabolism

• Dilution:

  WB 1:500, IHC 1:50

• Form:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Buffer:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Function:

  Druggable Genome

• Storage Conditions:

  Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  PDE10A

• Overview:

  Carrier-free (BSA/glycerol-free) PDE10A mouse monoclonal antibody, clone LBI1C9

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=10846

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9Y233