ERCC1 Mouse Monoclonal Antibody [Clone ID: LBI1A3]

• Background:

  The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.

• Synonyms:

  COFS4; RAD10; UV20

• Gene Name:

  Homo sapiens ERCC excision repair 1, endonuclease non-catalytic subunit (ERCC1), transcript variant 2, mRNA.

• Gene ID:

  2067

• UniProt:

  P07992

• Conjugation:

  Unconjugated

• Related Pathways:

  Nucleotide excision repair

• Field of Research:

  Nucleotide excision repair

• Dilution:

  WB 1:2000, IHC 1:50, IF 1:100, Flow 1:100

• Form:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Buffer:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Function:

  Druggable Genome

• Storage Conditions:

  Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  ERCC1

• Overview:

  Carrier-free (BSA/glycerol-free) ERCC1 mouse monoclonal antibody, clone LBI1A3

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=2067

• Uniprot URL:

  https://www.uniprot.org/uniprot/P07992