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P63 (TP63) Mouse Monoclonal Antibody [Clone ID: UMLBI4]

CAT: 0882-AMM21755VCFSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0882-AMM21755VCFSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3) ; split-hand/foot malformation 4 (SHFM4) ; ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth) ; limb-mammary syndrome; Rap-Hodgkin syndrome (RHS) ; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.
Overview
TP63 mouse monoclonal antibody, clone UMLBI4
Synonyms
AIS; B (p51A) ; B (p51B) ; EEC3; KET; LMS; NBP; OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4; TP53CP; TP53L; TP73L
Gene Name
Homo sapiens tumor protein p63 (TP63), transcript variant 1, mRNA.
Gene ID
8626
UniProt
Q9H3D4
Conjugation
Unconjugated
Dilution
WB 1:500, IHC 1:200
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Function
Druggable Genome, Transcription Factors
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
TP63
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=8626
Uniprot URL
https://www.uniprot.org/uniprot/Q9H3D4

UniProtKB · Q9H3D4

Tumor protein 63

P63_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9H3D4
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TP63
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
p63
EC number
—
Processing
—
Secondary accessions
O75080, O75195, O75922, O76078, Q6VEG2, Q6VEG3, Q6VEG4, Q6VFJ1, Q6VFJ2, Q6VFJ3, Q6VH20, Q7LDI3, Q7LDI4, Q7LDI5, Q96KR0, Q9H3D2, Q9H3D3, Q9H3P8, Q9NPH7, Q9P1B4, Q9P1B5, Q9P1B6, Q9P1B7, Q9UBV9, Q9UE10, Q9UP26, Q9UP27, Q9UP28, Q9UP74
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDevelopmental proteinDNA-binding

Coding sequence diversity

Alternative promoter usageAlternative splicing

Biological process

ApoptosisNotch signaling pathwayTranscriptionTranscription regulation

Disease

Disease variantEctodermal dysplasiaPremature ovarian failure

PTM

Isopeptide bondUbl conjugation

Ligand

Metal-bindingZinc

Cellular component

Nucleus

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