CD16 (FCGR3A) Mouse Monoclonal Antibody [Clone ID: LBI2A2]

• Background:

  This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

• Synonyms:

  CD16; CD16A; FCG3; FCGR3; FCGRIII; FCR-10; FCRIII; FCRIIIA; IGFR3; IMD20

• Gene Name:

  Homo sapiens Fc fragment of IgG receptor IIIa (FCGR3A), transcript variant 3, mRNA.

• Gene ID:

  2214

• UniProt:

  P08637

• Conjugation:

  Unconjugated

• Related Pathways:

  Fc gamma R-mediated phagocytosis, Natural killer cell mediated cytotoxicity, Systemic lupus erythematosus

• Field of Research:

  Fc gamma R-mediated phagocytosis, Natural killer cell mediated cytotoxicity, Systemic lupus erythematosus

• Dilution:

  WB 1:1000, FLOW 1:100

• Form:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Buffer:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Function:

  ES Cell Differentiation/IPS, Secreted Protein, Transmembrane

• Storage Conditions:

  Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  FCGR3A

• Overview:

  Carrier-free (BSA/glycerol-free) FCGR3A mouse monoclonal antibody, clone LBI2A2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=2214

• Uniprot URL:

  https://www.uniprot.org/uniprot/P08637