DIP13B (APPL2) Mouse Monoclonal Antibody [Clone ID: LBI3D5]

• Background:

  The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t (12;22) (q24.1; q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011]

• Synonyms:

  DIP13B

• Gene Name:

  Homo sapiens adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (APPL2), transcript variant 1, mRNA.

• Gene ID:

  55198

• UniProt:

  Q8NEU8

• Conjugation:

  Unconjugated

• Dilution:

  WB 1:2000

• Form:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Buffer:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Storage Conditions:

  Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  APPL2

• Overview:

  Carrier-free (BSA/glycerol-free) APPL2 mouse monoclonal antibody, clone LBI3D5

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=55198

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8NEU8