PCSK9 Mouse Monoclonal Antibody [Clone ID: LBI8E10]

• Background:

  This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

• Synonyms:

  FH3; HCHOLA3; LDLCQ1; NARC-1; NARC1; PC9

• Gene Name:

  Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.

• Gene ID:

  255738

• UniProt:

  Q8NBP7

• Conjugation:

  Unconjugated

• Dilution:

  WB 1:500

• Form:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Buffer:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Function:

  Secreted Protein

• Storage Conditions:

  Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  PCSK9

• Overview:

  Carrier-free (BSA/glycerol-free) PCSK9 mouse monoclonal antibody, clone LBI8E10

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=255738

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8NBP7