BRCC36 (BRCC3) Mouse Monoclonal Antibody [Clone ID: LBI6G7]

• Background:

  This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]

• Synonyms:

  BRCC36; C6.1A; CXorf53

• Gene Name:

  Homo sapiens BRCA1/BRCA2-containing complex subunit 3 (BRCC3), transcript variant 1, mRNA.

• Gene ID:

  79184

• UniProt:

  P46736

• Conjugation:

  Unconjugated

• Dilution:

  WB 1:500

• Form:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Buffer:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Function:

  Druggable Genome, Protease

• Storage Conditions:

  Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  BRCC3

• Overview:

  Carrier-free (BSA/glycerol-free) BRCC3 mouse monoclonal antibody, clone LBI6G7

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=79184

• Uniprot URL:

  https://www.uniprot.org/uniprot/P46736