DR5 (TNFRSF10B) Mouse Monoclonal Antibody [Clone ID: LBI4B12]

• Background:

  The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]

• Synonyms:

  CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9

• Gene Name:

  Homo sapiens TNF receptor superfamily member 10b (TNFRSF10B), transcript variant 2, mRNA.

• Gene ID:

  8795

• UniProt:

  O14763

• Conjugation:

  Unconjugated

• Related Pathways:

  Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity, p53 signaling pathway

• Field of Research:

  Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity, p53 signaling pathway

• Dilution:

  WB 1:500, IHC 1:150

• Form:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Buffer:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Function:

  Druggable Genome, Transmembrane

• Storage Conditions:

  Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  TNFRSF10B

• Overview:

  Carrier-free (BSA/glycerol-free) TNFRSF10B mouse monoclonal antibody, clone LBI4B12

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=8795

• Uniprot URL:

  https://www.uniprot.org/uniprot/O14763