NEDD4 Mouse Monoclonal Antibody [Clone ID: LBI5A8]

• Background:

  This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]

• Synonyms:

  NEDD4-1; RPF1

• Gene Name:

  Neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase

• Gene ID:

  4734

• UniProt:

  P46934

• Conjugation:

  Unconjugated

• Related Pathways:

  Endocytosis, Ubiquitin mediated proteolysis

• Field of Research:

  Endocytosis, Ubiquitin mediated proteolysis

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500

• Form:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Buffer:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Function:

  Druggable Genome

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  NEDD4

• Overview:

  NEDD4 mouse monoclonal antibody, clone LBI5A8

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=4734

• Uniprot URL:

  https://www.uniprot.org/uniprot/P46934