UBE1C (UBA3) Mouse Monoclonal Antibody [Clone ID: LBI1B9]

• Background:

  The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  HUBA3; NAE2; UBE1C

• Gene Name:

  Ubiquitin like modifier activating enzyme 3

• Gene ID:

  9039

• UniProt:

  Q8TBC4

• Conjugation:

  Unconjugated

• Related Pathways:

  Ubiquitin mediated proteolysis

• Field of Research:

  Ubiquitin mediated proteolysis

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500

• Form:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Buffer:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  UBA3

• Overview:

  UBA3 mouse monoclonal antibody, clone LBI1B9

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=9039

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8TBC4