Factor X (F10) Mouse Monoclonal Antibody [Clone ID: LBI3A9]

• Background:

  This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway) . The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]

• Synonyms:

  FX; FXA

• Gene Name:

  Coagulation factor X

• Gene ID:

  2159

• UniProt:

  P00742

• Conjugation:

  Unconjugated

• Related Pathways:

  Complement and coagulation cascades

• Field of Research:

  Complement and coagulation cascades

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:2000

• Form:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Buffer:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Function:

  Druggable Genome, Protease, Transmembrane

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  F10

• Overview:

  F10 mouse monoclonal antibody, clone LBI3A9

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=2159

• Uniprot URL:

  https://www.uniprot.org/uniprot/P00742