SDHB Mouse Monoclonal Antibody [Clone ID: LBI1H6]

• Background:

  Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]

• Synonyms:

  CWS2; IP; MC2DN4; PGL4; SDH; SDH1; SDH2; SDHIP

• Gene Name:

  Succinate dehydrogenase complex iron sulfur subunit B

• Gene ID:

  6390

• UniProt:

  P21912

• Conjugation:

  Unconjugated

• Related Pathways:

  Alzheimer's disease, Citrate cycle (TCA cycle), Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease

• Field of Research:

  Alzheimer's disease, Citrate cycle (TCA cycle), Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:2000, IHC 1:150

• Form:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Buffer:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Function:

  Druggable Genome

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  SDHB

• Overview:

  SDHB mouse monoclonal antibody, clone LBI1H6

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=6390

• Uniprot URL:

  https://www.uniprot.org/uniprot/P21912