Apolipoprotein E (APOE) Mouse Monoclonal Antibody [Clone ID: LBI2A4]

• Background:

  Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jul 2008]

• Synonyms:

  AD2; APO-E; LDLCQ5; LPG

• Gene Name:

  Apolipoprotein E

• Gene ID:

  348

• UniProt:

  P02649

• Conjugation:

  Unconjugated

• Related Pathways:

  Alzheimer's disease

• Field of Research:

  Alzheimer's disease

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500, IHC 1:150

• Form:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Buffer:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Function:

  Adult stem cells, Druggable Genome, Secreted Protein, Stem cell - Pluripotency

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  APOE

• Overview:

  APOE mouse monoclonal antibody, clone LBI2A4

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=348

• Uniprot URL:

  https://www.uniprot.org/uniprot/P02649