BCL10 Mouse Monoclonal Antibody [Clone ID: LBI4G4]

• Background:

  This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]

• Synonyms:

  C-E10; CARMEN; CIPER; CLAP; IMD37; mE10

• Gene Name:

  B-cell CLL/lymphoma 10

• Gene ID:

  8915

• UniProt:

  O95999

• Conjugation:

  Unconjugated

• Related Pathways:

  B cell receptor signaling pathway, T cell receptor signaling pathway

• Field of Research:

  B cell receptor signaling pathway, T cell receptor signaling pathway

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:2000, IHC 1:150

• Form:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Buffer:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Function:

  Druggable Genome

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  BCL10

• Overview:

  BCL10 mouse monoclonal antibody, clone LBI4G4

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=8915

• Uniprot URL:

  https://www.uniprot.org/uniprot/O95999