PVRL1 (NECTIN1) Mouse Monoclonal Antibody [Clone ID: LBI1B6]

• Background:

  This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium (2+) -independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P) . Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq]

• Synonyms:

  CD111; CLPED1; ED4; HIgR; HV1S; HVEC; nectin-1; OFC7; PRR; PRR1; PVRL1; PVRR; PVRR1; SK-12

• Gene Name:

  Nectin cell adhesion molecule 1

• Gene ID:

  5818

• UniProt:

  Q15223

• Conjugation:

  Unconjugated

• Related Pathways:

  Adherens junction, Cell adhesion molecules (CAMs)

• Field of Research:

  Adherens junction, Cell adhesion molecules (CAMs)

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:2000, IHC 1:150, IF 1:100

• Form:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Buffer:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Function:

  Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  PVRL1

• Overview:

  PVRL1 mouse monoclonal antibody, clone LBI1B6

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=5818

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q15223