RASSF1 Mouse Monoclonal Antibody [Clone ID: LBI3C2]

• Background:

  This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

• Synonyms:

  123F2; NORE2A; RASSF1A; RDA32; REH3P21

• Gene Name:

  Ras association domain family member 1

• Gene ID:

  11186

• UniProt:

  Q9NS23

• Conjugation:

  Unconjugated

• Related Pathways:

  Bladder cancer, Non-small cell lung cancer, Pathways in cancer

• Field of Research:

  Bladder cancer, Non-small cell lung cancer, Pathways in cancer

• Concentration:

  0.48 mg/ml

• Dilution:

  WB 1:500, IF 1:100

• Form:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Buffer:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Function:

  Druggable Genome

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  RASSF1

• Overview:

  RASSF1 mouse monoclonal antibody, clone LBI3C2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=11186

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9NS23