Pyruvate Kinase (PKLR) Mouse Monoclonal Antibody [Clone ID: LBI1F3]

• Background:

  The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA) . Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

• Synonyms:

  PK1; PKL; PKR; PKRL; RPK

• Gene Name:

  Pyruvate kinase L/R

• Gene ID:

  5313

• UniProt:

  P30613

• Conjugation:

  Unconjugated

• Related Pathways:

  Glycolysis / Gluconeogenesis, Insulin signaling pathway, Maturity onset diabetes of the young, Metabolic pathways, Purine metabolism, Pyruvate metabolism, Type II diabetes mellitus

• Field of Research:

  Glycolysis / Gluconeogenesis, Insulin signaling pathway, Maturity onset diabetes of the young, Metabolic pathways, Purine metabolism, Pyruvate metabolism, Type II diabetes mellitus

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:2000, IF 1:100, FLOW 1:100

• Form:

  PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Buffer:

  PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Function:

  Druggable Genome

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  PKLR

• Overview:

  Anti-PKLR mouse monoclonal antibody, clone LBI1F3

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=5313

• Uniprot URL:

  https://www.uniprot.org/uniprot/P30613