PKA R2 (PRKAR2A) Mouse Monoclonal Antibody [Clone ID: LBI1C4]

• Background:

  CAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER) .

• Synonyms:

  PKR2; PRKAR2

• Gene Name:

  Protein kinase cAMP-dependent type II regulatory subunit alpha

• Gene ID:

  5576

• UniProt:

  P13861

• Conjugation:

  Unconjugated

• Related Pathways:

  Apoptosis, Insulin signaling pathway

• Field of Research:

  Apoptosis, Insulin signaling pathway

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:2000, IHC 1:50, IF 1:100, Flow: 1:100

• Form:

  PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Buffer:

  PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Function:

  Druggable Genome

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  PRKAR2A

• Overview:

  Anti-PRKAR2A (PKA R2) mouse monoclonal antibody, clone LBI1C4

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=5576

• Uniprot URL:

  https://www.uniprot.org/uniprot/P13861