HIPPI (IFT57) Mouse Monoclonal Antibody [Clone ID: LBI2G3]

• Background:

  Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity) . Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3'present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear

• Synonyms:

  ESRRBL1; HIPPI; MHS4R2

• Gene Name:

  Intraflagellar transport 57

• Gene ID:

  55081

• UniProt:

  Q9NWB7

• Conjugation:

  Unconjugated

• Related Pathways:

  Huntington's disease

• Field of Research:

  Huntington's disease

• Concentration:

  0.71 mg/ml

• Dilution:

  WB 1:1000, IHC 1:50, IF 1:100

• Form:

  PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Buffer:

  PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Function:

  Druggable Genome

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  IFT57

• Overview:

  Anti-IFT57 (HIPPI) mouse monoclonal antibody, clone LBI2G3

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=55081

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9NWB7