MEK4 (MAP2K4) Mouse Monoclonal Antibody [Clone ID: LBI2D5]

• Background:

  This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.

• Synonyms:

  JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4; SAPKK-1; SAPKK1; SEK1; SERK1; SKK1

• Gene Name:

  Mitogen-activated protein kinase kinase 4

• Gene ID:

  6416

• UniProt:

  P45985

• Conjugation:

  Unconjugated

• Related Pathways:

  Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Fc epsilon RI signaling pathway, GnRH signaling pathway, MAPK signaling pathway, Toll-like receptor signaling pathway

• Field of Research:

  Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Fc epsilon RI signaling pathway, GnRH signaling pathway, MAPK signaling pathway, Toll-like receptor signaling pathway

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:2000, IHC 1:150, IF 1:100, IP 2ug/500ul

• Form:

  PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Buffer:

  PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Function:

  Druggable Genome, Protein Kinase

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  MAP2K4

• Overview:

  Anti-MAP2K4 (MEK4) mouse monoclonal antibody, clone LBI2D5

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=6416

• Uniprot URL:

  https://www.uniprot.org/uniprot/P45985