L3MBTL1 Antibody (Center) [APR33355G]

• Background:

  Tissue Location: Widely expressed. Expression is reduced in colorectal cancer cell line SW480 and promyelocytic leukemia cell line HL-60.

• Synonyms:

  Lethal (3) malignant brain tumor-like protein 1, H-l (3) mbt, H-l (3) mbt protein, L (3) mbt-like, L (3) mbt protein homolog, L3MBTL1, L3MBTL1, KIAA0681, L3MBT, L3MBTL

• Gene Name:

  L3MBTL1

• Gene ID:

  26013

• UniProt:

  Q9Y468

• Chromosomal Location:

  Nucleus. Note=Excluded from the nucleolus. Does not colocalizes with the PcG protein BMI1, suggesting that these two proteins do not belong to the same complex

• Applications:

  WB

• Dilution:

  WB--1:2000

• Function:

  Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53- target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys- 860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.

• Molecular Weight:

  92297

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality L3MBTL1 Antibody (Center) [APR33355G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=26013

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9Y468