LMNA (Lamin-A/C) Antibody (Center) [APR33079G]

• Background:

  Tissue Location: In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress.

• Synonyms:

  Prelamin-A/C, Lamin-A/C, 70 kDa lamin, Renal carcinoma antigen NY-REN-32, LMNA, LMN1

• Gene Name:

  LMNA

• Gene ID:

  4000

• UniProt:

  P02545

• Chromosomal Location:

  Nucleus. Nucleus envelope. Nucleus lamina. Nucleus, nucleoplasm Nucleus matrix. Note=Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleavage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C

• Applications:

  WB

• Dilution:

  WB--1:500 WB--1:1000

• Function:

  3154860610080180224310961081472611799477185515131207550615317753186119801058758510580070129274311861198023666920

• Molecular Weight:

  74139

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality LMNA (Lamin-A/C) Antibody (Center) [APR33079G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=4000

• Uniprot URL:

  https://www.uniprot.org/uniprot/P02545