Mouse Ring1 Antibody (C-term) [APR32946G]

• Synonyms:

  E3 ubiquitin-protein ligase RING1, 632-, Polycomb complex protein RING1, RING finger protein 1, Transcription repressor Ring1A, Ring1, Ring1A, Rnf1

• Gene Name:

  Ring1

• Gene ID:

  19763

• UniProt:

  O35730

• Chromosomal Location:

  Nucleus speckle.

• Applications:

  WB

• Dilution:

  WB--1:1000

• Function:

  Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity) .

• Molecular Weight:

  42631

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Mouse Ring1 Antibody (C-term) [APR32946G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=19763

• Uniprot URL:

  https://www.uniprot.org/uniprot/O35730