PARK7 Antibody (C-term) [APR32888G]

• Background:

  Tissue Location: Highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart. Detected at slightly lower levels in placenta and brain (at protein level) . Detected in astrocytes, Sertoli cells, spermatogonia, spermatids and spermatozoa. Expressed by pancreatic islets at higher levels than surrounding exocrine tissues (PubMed:22611253) .

• Synonyms:

  Protein DJ-1, 34--, Oncogene DJ1, Parkinson disease protein 7, PARK7

• Gene Name:

  HGNC:16369

• Gene ID:

  11315

• UniProt:

  Q99497

• Chromosomal Location:

  Cell membrane {ECO:0000250|UniProtKB:Q99LX0}; Lipid-anchor {ECO:0000250|UniProtKB:Q99LX0}. Cytoplasm. Nucleus. Membrane raft {ECO:0000250|UniProtKB:O88767}. Mitochondrion. Endoplasmic reticulum. Note=Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against oxidative damage (PubMed:18711745) . Detected in tau inclusions in brains from neurodegenerative disease patients (PubMed:14705119) . Membrane raft localization in astrocytes and neuronal cells requires palmitoylation

• Applications:

  WB, IHC-P

• Dilution:

  IHC-P--1:100~500 WB--1:2000

• Function:

  1701583420304780187117451279648219229105254167852699508728993701126120531550287414749723170158342109751018711745254167852859630927903648316536962541678528013050269950872859630930150385301503853089453122523093316536962899370116390825192291051663248618711745238470461862600923792957

• Molecular Weight:

  19891

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PARK7 Antibody (C-term) [APR32888G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=11315

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q99497