Park6 (PINK1) Antibody (C-term) [APR32282G]

• Background:

  Tissue Location: Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development

• Synonyms:

  Serine/threonine-protein kinase PINK1, mitochondrial, BRPK, PTEN-induced putative kinase protein 1, PINK1

• Gene Name:

  PINK1

• Gene ID:

  65018

• UniProt:

  Q9BXM7

• Chromosomal Location:

  Mitochondrion outer membrane; Single-pass membrane protein. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q99MQ3}; Single-pass membrane protein. Cytoplasm, cytosol. Note=Localizes mostly in mitochondrion and the two smaller proteolytic processed fragments localize mainly in cytosol (PubMed:19229105) . When mitochondria lose mitochondrial membrane potential following damage, PINK1 import is arrested, which induces its accumulation in the outer mitochondrial membrane, where it acquires kinase activity (PubMed:18957282)

• Applications:

  WB

• Dilution:

  WB--1:1000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  146073341895728218443288150875081922910519966284204041072239665720798600236200512375428223933751246608062489885524751536247845822489617925527291324843002054714418443288236200512489885520798600204041071996628432484300223966573204703315087508199662842040410720798600237542822466080624751536247845822547400725527291199662842040410720798600237542822466080624751536247845822547400725527291320470331460733420798600204041071996628423933751150875081844328823620051248988551844328823620051184432883248430022396657

• Molecular Weight:

  62769

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Park6 (PINK1) Antibody (C-term) [APR32282G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=65018

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9BXM7