OAS3 Antibody (C-term) [APR32258G]

• Background:

  Tissue Location: Present at high level in placenta trophoblast.

• Synonyms:

  2'-5'-oligoadenylate synthase 3, (2-5') oligo (A) synthase 3, 2-5A synthase 3, p100 OAS, p100OAS, OAS3

• Gene Name:

  OAS3

• Gene ID:

  4940

• UniProt:

  Q9Y6K5

• Chromosomal Location:

  Cytoplasm. Nucleus.

• Applications:

  WB

• Dilution:

  WB--1:1000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

• Function:

  Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV) .

• Molecular Weight:

  121170

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality OAS3 Antibody (C-term) [APR32258G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=4940

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9Y6K5