Mouse Trem2 Antibody (N-term) [APR31807G]

• Background:

  Tissue Location: Expressed in the brain, specifically in microglia (at protein level) (PubMed:15728241, PubMed:28802038, PubMed:28855301, PubMed:28077724, PubMed:28592261, PubMed:29794134, PubMed:29752066, PubMed:27477018, PubMed:28559417) . Expressed in macrophages (at protein level) (PubMed:11241283, PubMed:28802038, PubMed:28559417) . Expressed at higher levels in the CNS, heart and lung than in lymph nodes or in other non-lymphoid tissues such as kidney, liver and testis (PubMed:12472885) . In the CNS not all microglia express TREM2 (PubMed:12472885) . Brain regions with an incomplete blood-brain barrier had the lowest percentages of TREM2 expressing microglia, whereas the lateral entorhinal and cingulate cortex had the highest percentages (PubMed:12472885) .

• Synonyms:

  Triggering receptor expressed on myeloid cells 2, TREM-2, Triggering receptor expressed on monocytes 2, Trem2, Trem2a, Trem2b, Trem2c

• Gene Name:

  Trem2

• Gene ID:

  83433

• UniProt:

  Q99NH8

• Chromosomal Location:

  [Isoform 1]: Cell membrane; Single-pass type I membrane protein

• Applications:

  IHC-P-Leica, WB

• Dilution:

  IHC-P-Leica--1:500 WB--1:500-1000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  112412832747701829518356274770182951835627477018280777242499088115728241285922612975206625631124302322632966364928483841298590942966364928592261288020383054831229752066256311241895769316418779

• Molecular Weight:

  24527

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Mouse Trem2 Antibody (N-term) [APR31807G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=83433

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q99NH8