ZNF385A Antibody (N-term) [APR31589G]

• Background:

  Tissue Location: Expressed predominantly in the retina.

• Synonyms:

  Zinc finger protein 385A, Hematopoietic zinc finger protein, Retinal zinc finger protein, ZNF385A, HZF, RZF, ZNF385

• Gene Name:

  ZNF385A

• Gene ID:

  25946

• UniProt:

  Q96PM9

• Chromosomal Location:

  Cytoplasm. Nucleus, nucleolus. Cell projection, dendrite. Note=Detected in dendrites of Purkinje cells and hippocampal neurons.

• Applications:

  WB

• Dilution:

  WB--1:1000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'- UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell- cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation.

• Molecular Weight:

  40454

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ZNF385A Antibody (N-term) [APR31589G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=25946

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q96PM9