COL8A2 Antibody (C-term) [APR30857G]

• Background:

  Tissue Location: Expressed primarily in the subendothelium of large blood vessels. Also expressed in arterioles and venules in muscle, heart, kidney, spleen, umbilical cord, liver and lung and is also found in connective tissue layers around hair follicles, around nerve bundles in muscle, in the dura of the optic nerve, in cornea and sclera, and in the perichondrium of cartilaginous tissues. In the kidney, expressed in mesangial cells, glomerular endothelial cells, and tubular epithelial cells. Also expressed in mast cells, and in astrocytes during the repair process. Expressed in Descemet's membrane

• Synonyms:

  Collagen alpha-2 (VIII) chain, Endothelial collagen, COL8A2

• Gene Name:

  COL8A2

• Gene ID:

  1296

• UniProt:

  P25067

• Chromosomal Location:

  Secreted, extracellular space, extracellular matrix, basement membrane

• Applications:

  IHC-P-Leica, IF, WB

• Dilution:

  IHC-P-Leica--1:500 WB--1:2000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity) .

• Molecular Weight:

  67244

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality COL8A2 Antibody (C-term) [APR30857G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=1296

• Uniprot URL:

  https://www.uniprot.org/uniprot/P25067