FGF2 Antibody (Center) [APR30551G]

• Background:

  Tissue Location: Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.

• Synonyms:

  Fibroblast growth factor 2, FGF-2, Basic fibroblast growth factor, bFGF, Heparin-binding growth factor 2, HBGF-2, FGF2, FGFB

• Gene Name:

  FGF2

• Gene ID:

  2247

• UniProt:

  P09038

• Chromosomal Location:

  Secreted. Nucleus. Note=Exported from cells by an endoplasmic reticulum (ER) /Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (PubMed:20230531) . Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol (PubMed:22321063) . Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (PubMed:22321063)

• Applications:

  WB, IHC-P, IF

• Dilution:

  WB--1:2000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  86630442830267728302677866304428302677172161539642593732516234691072830267729501879

• Molecular Weight:

  30770

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality FGF2 Antibody (Center) [APR30551G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=2247

• Uniprot URL:

  https://www.uniprot.org/uniprot/P09038