PRMT2 Antibody (N-term) [APR30536G]

• Background:

  Tissue Location: Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord.

• Synonyms:

  Protein arginine N-methyltransferase 2, 211-, Histone-arginine N-methyltransferase PRMT2, PRMT2, HMT1, HRMT1L1

• Gene Name:

  PRMT2

• Gene ID:

  3275

• UniProt:

  P55345

• Chromosomal Location:

  [Isoform 1]: Cytoplasm. Nucleus. Note=Translocates from the cytoplasm to the nucleus, after hormone exposure. Excluded from nucleolus [Isoform PRMT2Beta]: Cytoplasm. Nucleus. Nucleus, nucleolus [Isoform PRMT2L2]: Cytoplasm. Nucleus Note=Predominantly cytoplasmic

• Applications:

  IHC-P, WB

• Dilution:

  IHC-P--1:100~500 WB--1:1000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

• Function:

  Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR) - mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER) -mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1- dependent manner) . May be involved in growth regulation.

• Molecular Weight:

  49042

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PRMT2 Antibody (N-term) [APR30536G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=3275

• Uniprot URL:

  https://www.uniprot.org/uniprot/P55345