Phospho-H3 (S10) Antibody [APR30510G]

• Synonyms:

  Histone H31, Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/i, Histone H3/j, Histone H3/k, Histone H3/l, HIST1H3A, H3FA

• Gene Name:

  HGNC:4766

• Gene ID:

  8350;8351;8352;8353;8354;8355;8356;8357;8358;8968

• UniProt:

  P68431

• Chromosomal Location:

  Nucleus. Chromosome.

• Applications:

  WB, IHC-P

• Dilution:

  WB--1:1000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is first purified by protein G affinity chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

• Function:

  Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

• Molecular Weight:

  15404

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-H3 (S10) Antibody [APR30510G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=8350;8351;8352;8353;8354;8355;8356;8357;8358;8968

• Uniprot URL:

  https://www.uniprot.org/uniprot/P68431