H2AFX Antibody (N-term) [AMM22155G]

• Synonyms:

  Histone H2AX, H2a/x, Histone H2AX, H2AFX, H2AX

• Gene Name:

  HGNC:4739

• Gene ID:

  3014

• UniProt:

  P16104

• Chromosomal Location:

  Nucleus. Chromosome

• Applications:

  WB, IHC-P

• Dilution:

  IHC-P--1:100~500 WB--1:1000

• Form:

  Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

• Function:

  Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

• Molecular Weight:

  15145

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality H2AFX Antibody (N-term) [AMM22155G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=3014

• Uniprot URL:

  https://www.uniprot.org/uniprot/P16104