RAB23 Antibody [AMM22130G]

• Synonyms:

  Ras-related protein Rab-23, RAB23

• Gene Name:

  RAB23

• Gene ID:

  51715

• UniProt:

  Q9ULC3

• Chromosomal Location:

  Cell membrane {ECO:0000250|UniProtKB:P35288}; Lipid-anchor; Cytoplasmic side {ECO:0000250|UniProtKB:P35288}. Cytoplasm. Cytoplasmic vesicle, autophagosome. Endosome membrane {ECO:0000250, ECO:0000250|UniProtKB:P35288}. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.

• Applications:

  WB, FC, IF

• Dilution:

  IF--1:25 FC--1:25 WB--1:2000

• Form:

  Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

• Function:

  The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes.

• Molecular Weight:

  26659

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality RAB23 Antibody [AMM22130G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=51715

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9ULC3