TIGIT Antibody [ApR05009G]

• Background:

  Tissue Location: Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level)

• Synonyms:

  T-cell immunoreceptor with Ig and ITIM domains, V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3, TIGIT, VSIG9, VSTM3

• Gene Name:

  TIGIT

• Gene ID:

  201633

• UniProt:

  Q495A1

• Chromosomal Location:

  Cell membrane; Single-pass type I membrane protein

• Applications:

  WB

• Dilution:

  WB--1:2000

• Function:

  Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

• Molecular Weight:

  26319

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TIGIT Antibody [ApR05009G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=201633

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q495A1