ADAM8/CD156a Protein, Rhesus, Recombinant (His Tag)

• Background:

  ADAM8, also known as CD156, is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM8 is possiblely involved in extravasation of leukocytes As a metalloprotease, ADAM8 also may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma.

• Gene Name:

  ADAM metallopeptidase domain 8

• Expression System:

  HEK293 Cells

• Tag:

  C-His

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 85 % as determined by SDS-PAGE.

• Activity:

  Measured by its ability to cleave a fluorogenic peptide substrate Mca-PLAQAV-Dpa-RSSSR-NH2, R&D Systems, Catalog # ES003.The specific activity is > 0.5 pmols/min/μg.

• Form:

  Liquid

• Buffer:

  Supplied as sterile 12.5mM Tris, 5mM CaCl2, 75mM NaCl, 50% glycerol. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hard copy of CoA.

• Function:

  CD Molecule proteins, Enzyme Proteins, Protease proteins

• Molecular Weight:

  The recombinant rhesus ADAM8 comprises 488 amino acids and has a calculated molecular mass of 53.6 KDa.

• Storage Conditions:

  Liquid. It is shipped out with blue ice. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ADAM8

• Species:

  Rhesus

• Protein ID:

  XP_002805919.1

• Overview:

  A DNA sequence encoding the rhesus ADAM8 (XP_002805919.1) (Met1-Pro497) was expressed with a polyhistidine tag at the C-terminus.

• AA Sequence:

  Met1-Pro497

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/protein/XP_002805919.1