SLC39A6/LIV-1 Protein, Cynomolgus, Recombinant (His Tag)

• Background:

  Along with the SLC30 family, SLC39 family members regulate zinc movement in cells. SLC39 metal ion transporters accumulate zinc into the cytosol. SLC39A6, also known as LIV-1, belongs to a new subfamily of Zrt, Irt-like protein zinc transporters (LZTs) . It is involved in maintaining the intracellular homeostasis of zinc, an ion that is essential in the control of cellular growth and differentiation. SLC39A6 plays a critical role in maintaining zinc homeostasis, and was originally identified as an estrogen-induced gene in a breast cancer cell line. Generally, elevated SLC39A6 expression is reportedly related to cancer progression in other various types of cancer, including breast, prostate, pancreatic, cervical and liver cancers.

• Gene Name:

  Solute carrier family 39 member 6

• Expression System:

  HEK293 Cells

• Tag:

  C-His

• Endotoxin:

  < 1.0 EU per μg protein as determined by the LAL method.

• Purity:

  > 95 % as determined by SDS-PAGE.

• Activity:

  Immobilized Cynomolgus SLC39A6/LIV-1 His (Cat:PK54000M2) at 2 μg/mL (100 μL/well) can bind Rabbit Anti-SLC39A6/LIV-1 Antibody (Cat:203773-T08), the ECof Rabbit Anti-SLC39A6/LIV-1 Antibody (Cat:203773-T08) is 15-100 ng/mL.

• Form:

  Lyophilized

• Buffer:

  Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

• Molecular Weight:

  The recombinant cynomolgus SLC39A6 consists of 299 amino acids and predicts a molecular mass of 34 kDa.

• Storage Conditions:

  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SLC39A6

• Species:

  Cynomolgus

• Protein ID:

  A0A2K5WH46-1

• Overview:

  A DNA sequence encoding the cynomolgus SLC39A6 (A0A2K5WH46-1) (Met1-Gln308) was expressed with a polyhistidine tag at the C-terminus.

• AA Sequence:

  Met1-Gln308

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/protein/A0A2K5WH46-1