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CD122/IL2RB Protein, Human, Recombinant

CAT: 0882-PH51058M0Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0882-PH51058M0Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Interleukin-2 receptor (IL-2R) also known as High-affinity IL-2 receptor subunit beta, IL-2 receptor subunit beta, and IL-2RB, is involved in T cell-mediated immune responses. CD122/IL-2RB is present in 3 forms concerning the ability to bind interleukin 2. The low-affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high-affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high-affinity forms of CD122/IL-2RB are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. CD122/IL-2RB expression was restricted to the earliest B220+ cells (CD43+CD24-; prepro B cells; fraction A) that proliferate vigorously to IL-2 in the absence of any stromal cells, but not to IL-15. The high-affinity form of this receptor is expressed on activated T lymphocytes, activated B lymphocytes, and activated macrophages. CD122/IL-2RB plays a role in regulating normal lymphocyte development.
Overview
The mature form of human IL2 Rβ (NP_000869.1) extracellular domain (Met 1-Asp 239) with five amino acids (DDDDK) at the C-terminus was expressed and purified.
Synonyms
CD122 Protein, Human; IL-15RB Protein, Human; IL15RB Protein, Human; P70-75 Protein, Human
Gene Name
Interleukin 2 receptor, beta
Expression System
HEK293 Cells
Tag
No tag
Field of Research
Neuroinflammation
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 90 % as determined by SDS-PAGE.
Activity
Measured by its ability to inhibit IL15-dependent proliferation of MO7e human megakaryocytic leukemic cells in the presence of 4.0 ng/mL of recombinant human IL-15. The EDfor this effect is 1-4μg/mL.
Form
Lyophilized
Buffer
Lyophilized from sterile 100mM NaCl, 50mM Tris, pH 7.5 Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Function
Cytokine Proteins, Interleukin proteins, Enzyme Proteins, CD Molecule proteins, Receptor Proteins
Molecular Weight
The mature recombinant human IL2 Rβ consists of 219 amino acids and has a predicted molecular mass of 25.2 kDa. As a result of glycosylation, the rh IL2 Rβ migrates as an approximately 40 kDa protein in SDS-PAGE under reducing conditions.
Storage Conditions
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
IL2RB
Species
Human
Protein ID
NP_000869.1
AA Sequence
Met1-Asp239
Protein ID Link
https://www.ncbi.nlm.nih.gov/protein/NP_000869.1

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