ELOA Antibody - C-terminal region: Biotin (P100692_T100-Biotin)

• Gene Name:

  Elongin A

• Gene Aliases:

  SIII, TCEB3, TCEB3A, SIII p110

• Gene ID:

  6924

• Swiss Prot:

  Q14241

• Accession Number:

  NP_003189

• Host:

  Rabbit

• Reactivity:

  Rat, Dog, Guinea Pig

• Immunogen:

  The immunogen is a synthetic peptide directed towards the C terminal region of human TCEB3

• Target:

  This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.

• Partner Proteins:

  KRTAP10-3; CEP57L1; SPERT; FAM9B; KRT40; CEP70; GMCL1; HOMEZ; TRIM54; MID2; PLK4; JAKMIP2; PSMB9; POLR2L; POLR2K; POLR2J; POLR2I; POLR2H; POLR2G; POLR2F; POLR2E; POLR2D; POLR2C; POLR2B; POLR2A; MDFI; UBC; RAD54B; MED26; ECT2; BARD1; CDK12; TCEB2; TCEB1; B

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Polyclonal Antibody

• Applications:

  IHC, WB

• Sample Type:

  TCEB3 is strongly supported by BioGPS gene expression data to be expressed in HEK293T

• Concentration:

  0.5 mg/mL

• Homology:

  Dog: 100%; Guinea Pig: 91%; Rat: 92%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  87kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  772

• NCBI Gene Symbol:

  ELOA

• Protein Name:

  Elongin-A

• Nucleotide Accession Number:

  NM_003198