MAP3K9 Antibody (Phospho-Thr312) : Biotin (OABF01750-Biotin)

• Gene Name:

  Mitogen-activated protein kinase kinase kinase 9

• Gene Aliases:

  MLK1, MEKK9, PRKE1

• Gene ID:

  4293

• Swiss Prot:

  P80192

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  KLH conjugated synthetic phosphopeptide derived from human MAP3K9 around the phosphorylation site of Thr312

• Target:

  Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Polyclonal Antibody

• Applications:

  IHC-P, IF

• Purification:

  Purified by Protein A.

• Concentration:

  1 mg/mL

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Shipping Conditions:

  Wet Ice

• Fragment:

  IgG

• NCBI Gene Symbol:

  MAP3K9