Z-LEHD-FMK (TFA)

Z-LEHD-FMK (TFA)

• CAS Number: 524746-03-0
• UNSPSC Description: Z-LEHD-FMK TFA is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK TFA exhibits the neuroprotective effect in a rat model of spinal cord trauma[1][2][3].
• Target Antigen: Apoptosis; Caspase
• Type: Peptides
• Related Pathways: Apoptosis
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/z-lehd-fmk-tfa.html
• Solubility: H2O
• Smiles: OC(C(F)(F)F)=O.O=C(OCC1=CC=CC=C1)N[C@@H](CC(C)C)C(N[C@@H](CCC(OC)=O)C(N[C@H](C(N[C@H](C(CF)=O)CC(OC)=O)=O)CC2=CN=CN2)=O)=O
• Molecular Weight: 804.74
• References & Citations: [1]Ozoren N, et, al. The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. Cancer Res. 2000 Nov 15; 60(22): 6259-65.|[2]Colak A, et, al. Neuroprotection and functional recovery after application of the caspase-9 inhibitor z-LEHD-fmk in a rat model of traumatic spinal cord injury. J Neurosurg Spine. 2005 Mar; 2(3): 327-34.|[3]Mocanu MM, et, al. Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury. Br J Pharmacol. 2000 May; 130(2): 197-200.mSphere. 2024 May 17:e0023624.|Preprints. 2024 Aug 14.|Virol Sin. 2024 May 30:S1995-820X(24)00078-6.|Food Chem Toxicol. 2018 Oct;120:143-154.|Food Chem Toxicol. 2019 Oct;132:110655. |Food Chem Toxicol. 2020 Dec;146:111843.|J Cell Mol Med. 2019 Apr;23(4):2489-2504.|J Cell Mol Med. 2020 Jul;24(14):8151-8165.|Oxid Med Cell Longev. 26 Jun 2022.|Sci Adv. 2023 Oct 6;9(40):eadi6586.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported