ATP6V1B1 Antibody - N-terminal region: FITC (ARP74408_P050-FITC)

• Gene Name:

  ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1

• Gene Aliases:

  VATB, VMA2, VPP3, DRTA2, RTA1B, ATP6B1

• Gene ID:

  525

• Swiss Prot:

  P15313

• Accession Number:

  NP_001683.2

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  The immunogen for Anti-ATP6V1B1 antibody is: synthetic peptide directed towards the N-terminal region of Human VATB1

• Target:

  This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness.

• Clonality:

  Polyclonal

• Conjugation:

  FITC: Fluorescein Isothiocyanate

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity purified

• Concentration:

  0.5 mg/mL

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  56 kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  513

• NCBI Gene Symbol:

  ATP6V1B1