RUNX3 Antibody - C-terminal region: Biotin (ARP74196_P050-Biotin)

• Gene Aliases:

  AML2, CBFA3, PEBP2aC

• Gene ID:

  864

• Swiss Prot:

  Q13761

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  The immunogen is a synthetic peptide directed towards the C-terminal region of Human RUNX3

• Target:

  This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

• Partner Proteins:

  Dlg4; UBC; PML; PIN1; NOTCH1; RBPJ; SIRT2; Cdk4; MDM2; EZH2; Vdr; SMURF2; SMURF1; HDAC9; SUV39H1; SMAD3; EP300; CBFB; SP110; HDAC5; HDAC4; HDAC2; HDAC1; TLE1; SMAD1; YAP1; SMAD5; SMAD2; PHB2

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity purified

• Concentration:

  0.5 mg/mL

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  45kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  415

• NCBI Gene Symbol:

  RUNX3