DDB1 Antibody - middle region: HRP (ARP73816_P050-HRP)

• Gene Aliases:

  XPE, DDBA, XAP1, XPCE, XPE-BF, UV-DDB1

• Gene ID:

  1642

• Swiss Prot:

  Q16531

• Accession Number:

  XP_005273861

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  The immunogen is a synthetic peptide directed towards the middle region of Human DDB1

• Target:

  The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.

• Partner Proteins:

  SAP30; DCAF5; CUL4B; HUWE1; DCAF15; DCAF17; SAP130; DDA1; SUDS3; DCAF6; AMBRA1; DET1; PHIP; DCAF16; ARID4B; DTL; DCAF4; SIN3A; DCAF12; WDTC1; RBP1; HDAC2; HDAC1; ERCC8; UBC; CEP72; vpr; HCVgp1; CRBN; CEP57; AURKB; RFWD2; CEP250; TUBGCP2; CHEK1; CDKN1A; TP

• Clonality:

  Polyclonal

• Conjugation:

  HRP: Horseradish Peroxidase

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Format:

  Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  125kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  1140

• NCBI Gene Symbol:

  DDB1