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Voriconazole-d3

CAT: 0804-HY-76200SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-76200SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Voriconazole-d3 is the deuterium labeled Voriconazole. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes[1][2].
CAS Number
1217661-14-7
Product Name Alternative
UK-109496-d3
UNSPSC
12352005
Hazard Statement
H301, H351, H360, H412
Target
Fungal
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection
Field of Research
Infection
Purity
99.90
Solubility
10 mM in DMSO|DMSO : ≥ 50mg/mL|H2O : 0.17mg/mL (ultrasonic)
Smiles
[2H]C([2H])([2H])[C@@H](C1=NC=NC=C1F)[C@@](O)(C2=C(C=C(C=C2)F)F)CN3C=NC=N3
Molecular Formula
C16H11D3F3N5O
Molecular Weight
352.33
Precautions
H301, H351, H360, H412
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Nickie D Greer. Voriconazole: the newest triazole antifungal agent.Proc (Bayl Univ Med Cent) . 2003 Apr;16 (2) :241-8.|[3]Lesley J Scott, et al. Voriconazole : a review of its use in the management of invasive fungal infections.Drugs. 2007;67 (2) :269-98.|[4]A M Sugar, et al. Efficacy of voriconazole in treatment of murine pulmonary blastomycosis.Antimicrob Agents Chemother. 2001 Feb;45 (2) :601-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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Alternative Products

CatalogName
RM-V180317-01Voriconazole-d3
AR-V01827-01(+-) -Voriconazole-d3
CS-C-01312(±) -Voriconazole-d3 (difluorophenyl-d3)
CS-T-101082Rac-Voriconazole-d3
BAA31496-01Ent-Voriconazole-d3
TRC-V760003-25MGVoriconazole-13C3,d3
MBS6088572-01Voriconazole-d3 N-Oxide
AR-V01835-01Voriconazole-N-Oxide-d3
TMIJ-0188-01(±) -Voriconazole-d3 (Mixture of Enantiomers)
022867Voriconazole-d3 N-Oxide discontinued

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